Biological Activity of Matricaria chamomilla Essential Oils of Various Chemotypes
2020
The essential oil of Matricaria chamomilla L., which is commonly used for
medicinal and cosmetic purposes, can be differentiated between several
chemotypes. In the current study, six essential chamomile oil samples of various
origins (four of commercial sources, one of cultivation, one of wild collection)
were examined regarding their composition and biological activities,
i. e., antibacterial, antifungal, mosquito repellent, and larvicidal
effects. GC-MS analyses revealed that the samples largely varied in composition
and could be attributed to various chemotypes. In contrast to the other two
samples, the four commercial samples were unusually high in
trans-β-farnesene. The overall antimicrobial effects
were only moderate, but it could be shown that a higher content in
α-bisabolol and a smaller in α-bisabolol
oxides A and B had a positive effect on overall activity. All samples had a
biting deterrent effect comparable to DEET. Higher concentrations of
(Z )- and (E )-spiroethers improved larvicidal
activity, whereas trans-β-farnesene had the opposite
effect. In conclusion, the importance of α-bisabolol for the
biological activity of chamomile essential oil could be demonstrated.
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