New insights in the production of aerosol antibiotics. Evaluation of the optimal aerosol production system for ampicillin-sulbactam, meropenem, ceftazidime, cefepime and piperacillin-tazobactam.

Abstract Background Several aerosol antibiotics are on the market and several others are currently being evaluated. Aim of the study was to evaluate the aerosol droplet size of five different antibiotics for future evaluation as an aerosol administration. Materials and methods The nebulizers Sunmist ® , Maxineb ® and Invacare ® were used in combination with four different “small Results Significant effect on the droplet size produced the different antibiotic ( F  = 96.657, p F  = 68.535, p p  = 0.127) and the nebulizer ( p  = 0.715). Interactions effects were found significant only between antibiotic and residual cup ( F  = 16.736, p Conclusion Our results firstly indicate us indirectly that the chemical formulation of the drug is the main factor affecting the produced droplet size and secondly but closely the residual cup design.