MATERIALS FOR ENSURING HUMAN LIFE ACTIVITY AND ENVIRONMENT PROTECTION A Biomedical Cell Product for the Regeneration of Articular Cartilage: Biocompatible and Histomorphological Properties (an Experimental Model of Subcutaneous Implantation)

An in vivo study of the biological safety of a biomedical cell product for regeneration of articular cartilage with subcutaneous implantation of cellengi neered cartilage tissue was carried out. A comparative study of the biological safety of the cellengineered co nstruct of human articular cartilage tissue (CEC hAT) and the biocompatible BMCH matrix in an implantation test did not show significant differences between the control and experimental groups. The results demonstrated that the cell component of the cellengineered construct of hAT is not a risk factor for its implantation for up to 28 days. During the study, some signs of for� mation of articular tissue were observed at the site of subcutaneous implantation of the CEC hAT. Consider� ing high proliferation and differentiation activity of the CEC hAT previously confirmed after its cultivation for 42 days, it is possible to suggest the potential of using CEC hAT for regeneration of injured cartilage as an injection form of biomedical cell product.