α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents
2007
In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of α-amino acids were screened for their in vitro H + /K + ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.
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