Bone Marrow “Yellow” and “Red” Adipocytes”: Good or Bad Cells?

Purpose of Review Replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow constitutes a physiological process associated with aging. Adipocytes have recently emerged as an active part of the bone marrow niche and exert paracrine and endocrine functions, thereby contributing to the regulation of hematopoiesis. Here, we review the current understanding of the interactions between bone marrow adipocytes (BMAs) and hematopoietic cells, as well as their potential role in the progression of hematological malignancies.