LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.
2015
Wnt signalling can be transmitted both through a canonical pathway, via the co-receptors LRP5/6, and through Frz in a non-canonical pathway. Here, the authors demonstrate a direct interaction between Frz and LRP5/6, describing a new mechanism for how these receptors are primed to respond to Wnt ligands.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
48
References
41
Citations
NaN
KQI