Dual targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes; rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.