Increasing Upstream Process Development Efficiency by Implementing Platform Glutamine Synthetase Cell Culture Processes
2010
By implementing platform processes for time- and labor-intensive development and optimization steps, it is possible to remove process development activities from the critical path to the clinic. One key component is the development of platform fed-batch cell culture processes for cell lines generated using the Glutamine Synthetase (GS) expression system (Lonza Biologics). The process consists of chemically-defined, animal-component-free base media that is specific for CHO or NS0 cell types, feed media used for CHO and NS0 and an elapsed IVCC-based method for feed rate determination.
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