Handbook of Analysis of Oligonucleotides and Related Products

Purity Analysis and Impurities Determination by Reversed-Phase High- Performance Liquid Chromatography H. Cramer, K. J. Finn, and E. Herzberg Purity Analysis and Impurities Determination by AEX-HPLC J. R. Thayer, V. Murugaiah, and Y. Wu Purity Analysis and Molecular Weight Determination by Size Exclusion HPLC Analysis M.F. Chan and I. Roymoulik Analysis of Oligonucleotides by Liquid Chromatography-Mass Spectrometry S. Pourshahian and S. M McCarthy Sequence Determination and Confirmation by MS/M S and MALDI-TOF Z. Timar Tm Analysis of Oligonucleotides H. Zhu and G. S. Srivatsa Purity and Content Analysis of Oligonucleotides by Capillary Gel Electrophoresis J.Carmody and B. Noll Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay Techniques H. Legakis and S. Carriero Oligonucleotide Assay and Potency D. P. Michaud Microbial Analysis: Endotoxin Testing B. J. Markley Analysis of Residual Solvents by Head Space Gas Chromatography S. Countryman and J. V. Bonilla Determination of Extinction Coefficient V. Murugaiah Structural Determination by NMR M. L. DeRider, D. Brooks, and G. Burt Infrared Analysis of Oligonucleotides J. V. Bonilla Stability Indicating Methods for Oligonucleotide Products V. Murugaiah Analysis by Hydrophilic Interaction Chromatography R. N. Easter and P. A. Limbach Determination of Base Composition H. Aygun Analysis of Metals in Oligonucleotides M. P. Murphy Regulatory Considerations for the Development of Oligonucleotide Therapeutics G. S. Srivatsa