Cytotoxic Activity of the Mesoionic Compound MIH 2.4Bl in Breast Cancer Cell Lines

Luciana Amaral de Mascena Costa,Ashlyn C. Harmon,Álvaro Aguiar Coelho Teixeira,Filipe Cássio Silva de Lima,Silvany de Sousa Araújo,Fabio Del Piero,Helivaldo Diógenes Da Silva Souza,Petrônio Filgueiras de Athayde-Filho,Severino Alves Júnior,Maria de Mascena Diniz Maia,Aurea Wischral,Manoel Adrião Gomes-Filho,J. Michael Mathis

Cytotoxic Activity of the Mesoionic Compound MIH 2.4Bl in Breast Cancer Cell Lines

2020

Luciana Amaral de Mascena Costa
Ashlyn C. Harmon
Álvaro Aguiar Coelho Teixeira
Filipe Cássio Silva de Lima
Silvany de Sousa Araújo
Fabio Del Piero
Helivaldo Diógenes Da Silva Souza
Petrônio Filgueiras de Athayde-Filho
Severino Alves Júnior
Maria de Mascena Diniz Maia
Aurea Wischral
Manoel Adrião Gomes-Filho
J. Michael Mathis

In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative of a mesoionic compound (MIH 2.4Bl) and the characterization of its selective cytotoxicity on a panel of breast c...

Keywords:

Apoptosis
Breast cancer
Cell cycle
selective cytotoxicity
breast cancer cell line
Cancer research
cancer therapy
Cytotoxic T cell
Mesoionic
Chemistry

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