Lactobacillus plantarum and Lactobacillus fermentum alone or in combination regulate intestinal flora composition and systemic immunity to alleviate obesity syndrome in high-fat diet rat

Summary Relationship between intestinal flora and obesity has aroused great interest. The probiotic effects of Lactobacillus plantarum (LP) and Lactobacillus fermentum (LF) have been documented extensively. This study aimed to explore the effects of LP and LF alone or in combination on lipid-lowering effects of the high-fat diet rat via intestinal flora modulation and systemic immunity. The rats in high-fat diet plus LP (LP 108 cfu day−1) showed significantly lower IL-6 and endotoxin (ET) content, increased the number of Bifidobacterium and Lactobacillus and decreased the liver steatosis and fat vehicle sizes. The Lactobacillus LP and LF in combination can regulate intestinal flora and systemic immune function in rats with high-fat diet. It provides the foundation for the further development and application of multiple Lactobacillus strain in controlling obesity-related syndrome.