Bolax gummifera: Toxicity against Artemia sp. of Bornyl and iso-Bornyl Esters

The bioaactivity-guided fractionation of a KB cells cytotoxic methanolic extract of Bolax gummifera using the Artemia sp.(brine shrimp) toxicity test (ATT), resulted in the isolation of racemic pcoumarate (1) and ferulate (2) of borneol as the active components. In order to study structure-activity relationships, optical active p-coumarates and ferulates of bornyl and isobornyl alcohols previously synthesised were tested in the ATT. The results show that the (+) isomers are more active that the (-) ones, and that the metoxil group in position 3 does not affect the toxicity against the brine shrimp.