G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

Chronic neuropathic pain is associated with K+ channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K+ channel–associated gene families caused by nerve injury. G9a in primary sensory neurons is a key epigenetic regulator involved in acute-to-chronic pain transition.