Formulation and In-Vitro Evaluation of sustained release Matrix Tabelts of Aceclofenac by using different natural polymars

The objective of this study was to develop a sustained release matrix tablet of aceclofenac using different natural polymers (Guargum, Xanthine gum, Chitosan) in various proportions as release controlling factor by direct compression method. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index and hausner rato etc. The drug polymer interaction was studied by FTIR and DSC thermal analysis. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro release studies. The in vitro dissolution study was carried out for 11 hours using United States Pharmacopoeia (USP) 1 Basket-type dissolution apparatus in 0.1N hydrochloric acid for first 2 hours and phosphate buffer pH 7.4 for 9 hours. The powder blend showed satisfactory flow properties. All the tablets complied with pharmacopoeial specifications. The in vitro release study shows that only F9 formulation was releases the drug in a sustained manner for 11 hours. From this study, a decrease in release kinetics of the drug was observed when the polymer concentration was increased. The drug release from these formulations was satisfactory after 3 months storage in 40C and 75% RH. Besides, this study explored the optimum concentration and effect of polymer(s) on acelofenac release pattern from the tablet matrix for 11 hour period.