Synthesis of 3-pyridyl [1, 2, 4] triazolo [3, 4-b] [1, 3, 4] thiadiazepines and evaluation of their antibacterial and antifungal activities

Some novel 3-pyridyl [1, 2, 4] triazolo [3, 4-b] [1, 3, 4] thiadiazepines derivatives were synthesized from substituted 4-amino 5-pyridine- 3-yl-1, 2, 4 triazole 3-thiol and substituted chalcones in the presence of glacial acetic acid and ethanol. Identification of the new compounds was established by Infra Red spectral data. All the synthesized compounds were tested for their in-vitro antibacterial and antifungal activities. The best activity was observed with compounds 3b, 3d, 3e.