Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.

Abstract A series of pyrazinones were prepared and evaluated as potential CRF 1 R PET imaging agents. Optimization of their CRF 1 R binding potencies and octanol–phosphate buffer phase distribution coefficients are discussed herein.