Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Vb Matthews,Mb Åström,Mhs Chan,Clinton R. Bruce,K. S. Krabbe,Oja Prelovsek,Thorbjorn Akerstrom,Christina Yfanti,Christa Broholm,Ole Hartvig Mortensen,Milena Penkowa,Pernille Hojman,Alaa Zankari,Matthew J. Watt,Helle Bruunsgaard,Bente Klarlund Pedersen,Mark A. Febbraio

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

2009

Vb Matthews
Mb Åström
Mhs Chan
Clinton R. Bruce
K. S. Krabbe
Oja Prelovsek
Thorbjorn Akerstrom
Christina Yfanti
Christa Broholm
Ole Hartvig Mortensen
Milena Penkowa
Pernille Hojman
Alaa Zankari
Matthew J. Watt
Helle Bruunsgaard
Bente Klarlund Pedersen
Mark A. Febbraio

Aims/hypothesis Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF.

Keywords:

AMP-activated protein kinase
Brain-derived neurotrophic factor
Skeletal muscle
Tropomyosin receptor kinase B
Myocyte
Neurotrophic factors
Cytokine
Endocrinology
Biology
Neuropeptide
Internal medicine
Receptor

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