Role for the MOV10 RNA helicase in Polycomb-mediated repression of the INK4a tumor suppressor

Evidence has indicated that non-coding RNAs are involved in gene repression by Polycomb complexes. MOV10, a putative RNA helicase, is now found to be associated with a human Polycomb protein and linked to Polycomb-mediated repression of the INK4a tumor suppressor, suggesting a role for RNA helicase activity in the silencing mechanism.