Resorbable Tightening of Blood Vessel Protheses Prepared from Synthetic Polymers

A method was prepared for the sealing of artificial blood vessels by combined soaking and spraying. Biocompatible and resorbable copolymers of poly(DL-lactide-co-glycolide) with varying contents of two co-monomers were used in the investigations. The materials were provided by Boehringer Ingelheim Co, Germany under the trade name Resomer. The polyester double-sided veloured knitted fabric vessel prosthesis DALLON H, by TRICOMED Co, constituted the matrix. Application trials resulted in the selection of Resomer RG 755S, containing 75% mol. residues of D,L-lactide and 25% mol. residues of glycolide. A modified polyester blood vessel prosthesis was prepared bearing the surgery tightness (water permeability below 30 ml/cm2/min) and physical-mechanical properties required, including elasticity adequate for such a medical device. Conditions for the sealing were elaborated at large laboratory scale with a notable composition of the coating bath and application of the coating. Results of the investigations can be considered as a basis for a technology layout for the sealing of artificial blood vessels with biocompatible and resorbable synthetic copolymer poly(DL-lactide-co-glycolide).