Antimicrobial profile of inducible clindamycin resistant strains of staphylococcus species

Introduction: The appearance of continuous resistant to multiple drugs among Staphylococci is a global burden due to its ability to cause severe infections. The selective use of drugs is necessary to overwhelm the situation. Taking in account present study was carried out to rule out true susceptibility of clindamycin towards staphylococcus species and its antimicrobial profile for judicial use of the drugs. Material and Methods: All the clinical samples received in the Department of microbiology were screened for Staphylococci as per standard guidelines which were further subjected to Antimicrobial susceptibility testing and D-test to detect MLSb phenotypes. Results: A total of 421 Staphylococcus species, 359(85.3%) were Staphylococcus aureus and 62(14.8%) were Coagulase negative Staphylococci; among them 42(10%) were Staphylococcus epidermidis& 20(4.8%) were Staphylococcus saprophyticus. D-test for S.aureus shows that 173(48.2%) inducible Clindamycin resistant, 113(31.5%) strains were constitutive MLSb phenotypes and 58(16.2%) strains shown to have MSb phenotypes. Among CoNS; among Staphylococcus epidermidis and S.saprophyticus 9.5% & 5% were Inducible Clindamycin resistance, 38.1% & 85% were constitutive MLSb phenotypes and 28.6%& 10% were MSb phenotypes respectively. All the isolates were sensitive to Linezolid, Vancomycin and Ceftaroline. Conclusion: Inducible clindamycin resistant strains of Staphylococci found to be among half of the strains, indicating that true susceptibility of clindamycin should be rule out on routine basis for proper institution of the therapy. Keywords: Staphylococci, MLSb phenotypes, AST.