Application of β-lactams in the synthesis of substance P antagonists: Preparation of 2-azabicyclo[3.3.1]nonane ring systems
1994
Abstract Intramolecular ureidomercuration of β-aminoacids synthesized from appropriate β-lactams provides an expeditious route to the synthesis of 2-aza-bicyclo[3.3.1]nonane ring systems. Synthesis of the locked-in chair conformer 2 of CP-99,994 is described.
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