INDEL polymorphisms at the DXS10146 flanking region in four racial populations

Abstract Insertion/deletion (INDEL) polymorphisms in the 3′ flanking region of the X chromosomal STR DXS10146 were analysed in the following four racial populations: 151 Japanese males, 60 Indonesian males and 90 South African males (32 Caucasians and 58 Africans). A 17-bp INDEL polymorphism in the 3′ flanking region was observed in all populations. In the African population, 4-bp and 7-bp INDEL polymorphisms were newly found 13bp and 25bp downstream of the core repeat unit of DXS10146, respectively. No samples with two or three deletions at these INDELs were observed in this study. In these four populations, all deletion events at the INDEL regions were observed only in alleles with six repeat number polymorphisms in the variable (TTCC) repeat block of the DXS10146 core repeat unit.