A 4-week consumption of medium roast and dark roast coffees affects parameters of energy status in healthy subjects

Abstract Scope This study intended to clarify whether two coffee brews, a market blend (MB) and a study blend (SB), containing equal amounts of caffeine, but differing in their contents of N-methylpyridinium, trigonelline and chlorogenic acids, differentially affect blood lipid profiles and glucose concentrations as well as blood platelet phosphodiesterase and lymphocyte energy charge potential in healthy volunteers. Methods and results In this double-blinded, randomized, controlled cross-over intervention study, 84 healthy normal-weight female and male volunteers consumed 750 mL of medium roast MB and dark roast SB coffee per day for 4 weeks. Following MB and SB coffee intervention, plasma free fatty acid concentrations equally increased ( p p Conclusion The results of this intervention study indicate that MB and SB coffees, although differing in contents of N-methylpyridinium, trigonelline and chlorogenic acids, largely exert similar biological effects as monitored by the biomarkers tested.