Preliminary screening of dominant epitopes of truncated p72 protein of African swine fever virus

2021 
African swine fever (ASF) causes huge economic losses in the absence of vaccines with protective efficacy. Diagnostic tools are critical for the early detection, prevention, and control of African swine fever virus (ASFV). The protein p72 is a good serological target for conducting ASF detection and surveillance. This study aimed to adopt a multiparameter analytic method to predict the dominant epitopes for p72 protein of ASFV based on a comprehensive analysis of the secondary structure, hydrophilicity, surface accessibility, and effects of the index of proteins using the software. The results showed that the area of the dominant epitope of protein p72 contained the N-terminal residues aa137–286. This study laid the foundation for developing vaccines and immunodiagnostic techniques.
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