Structure determination and synthesis of lysine isopeptides influencing on cell proliferation
1997
The clavicepamines are lysine-rich basic proteins isolated from saprophytic culture of ergot (Claviceps purpurea), having human pharmacological importance.
Based on structure determinations, it was demonstrated that the ϵ-lysine (poly)peptides are the fundamental structural units of clavicepamines.
To study the relationship between chemical structure and biological effect, solution and solid-phase synthesis of lysine isopeptides were performed. Poly-ϵ-lysines were synthesized with polycondensation via application of p-nitrophenylester temporarily protecting groups together with simultaneous activation. The biological investigations of poly-ϵ-lysines showed a cell-proliferation retarding effect, so they inhibit growth of some animal tumors, practically without toxic side effects. © 1997 John Wiley & Sons, Inc. Biopoly 42: 305–318, 1997
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