Total Synthesis of Nephilatoxin-8 (NPTX-8), a New Neurotoxin of Joro Spider (Nephila clavata)

The first synthesis of Nephilatoxin-8 (NPTX-8), a new neurotoxin of Joro spider (Nephila clavata), has been achieved by employing two key azide intermediates for the incorporation of the characteristic polyamines of the toxin, cadaverine and spermidine.