Synthesis and Antidepressant activity of 3, 4- dihydropyrimidin-2(1H)-ones

Derivatives of 3, 4- dihydropyrimidin-2(1H)-one and2, 5dioxo,4-aryl octahydroquinazolines were synthesized by microwave irradiation. The synthesized derivatives were characterized for physicochemical parameters and the spectroscopic studies. Compounds were screened for its antidepressant activity by using Tail Suspension Test (TST) and Forced Swim Test (FST) using fluoxetine as the standard. The duration of immobility measured in the control and animal groups treated with standard antidepressant drug (fluoxetine) and test drugs exhibited decrease in the immobility in both the models significantly and was comparable to the standard. Derivatives produced significant antidepressant activity in both the FST and TST in dose dependant manner.