Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Theodros Asberom,Thomas A. Bara,John W. Clader,William J. Greenlee,Henry Guzik,Hubert B. Josien,Wei Li,Eric M. Parker,Dmitri A. Pissarnitski,Lixin Song,Lili Zhang,Zhiqiang Zhao

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

2007

Theodros Asberom
Thomas A. Bara
John W. Clader
William J. Greenlee
Henry Guzik
Hubert B. Josien
Wei Li
Eric M. Parker
Dmitri A. Pissarnitski
Lixin Song
Lili Zhang
Zhiqiang Zhao

Abstract The development of a novel series of tetrahydroquinoline-derived γ-secretase inhibitors for the potential treatment of Alzheimer’s disease is described.

Keywords:

Amyloid precursor protein secretase
Biochemistry
Chemistry
γ secretase

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