A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

Melanie S. Vacchio,Lie Wang,Nicolas Bouladoux,Andrea C. Carpenter,Yumei Xiong,Linus C. Williams,Elizabeth A. Wohlfert,Ki-Duk Song,Yasmine Belkaid,Paul E. Love,Rémy Bosselut

A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

2014

Melanie S. Vacchio
Lie Wang
Nicolas Bouladoux
Andrea C. Carpenter
Yumei Xiong
Linus C. Williams
Elizabeth A. Wohlfert
Ki-Duk Song
Yasmine Belkaid
Paul E. Love
Rémy Bosselut

The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Bosselut and colleagues show that ThPOK maintains CD4+ T lineage integrity and is required for proper TH1 and TH2 differentiation.

Keywords:

DNA-binding protein
Immunology
Cell biology
Transcription factor
Cellular differentiation
Transcriptome
Effector
Biology
T cell
Core Binding Factor Alpha 3 Subunit
Molecular biology
Flow cytometry
mice transgenic
t cell differentiation

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