Synthesis of Spiro[isoquinolinone-4,2′-oxiranes] and Isoindolinones via a Multicomponent Reaction of 2-Acetyl-oxirane-2-carboxamides, Arylaldehydes and Malononitrile.

Depending on different intramolecular hydrogen bonding modes in diastereomeric 2-acetyl-oxirane-2-carboxamides (I) and (V), title compounds (IV) and (VI), resp., are formed in the multicomponent reaction with aryl aldehydes (II) and malodinitrile (III).