A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility

Bei Wei,Arttu Jolma,Biswajyoti Sahu,Lukas M. Orre,Fan Zhong,Fangjie Zhu,Teemu Kivioja,Inderpreet Sur,Janne Lehtiö,Minna Taipale,Jussi Taipale

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility

2018

Bei Wei
Arttu Jolma
Biswajyoti Sahu
Lukas M. Orre
Fan Zhong
Fangjie Zhu
Teemu Kivioja
Inderpreet Sur
Janne Lehtiö
Minna Taipale
Jussi Taipale

A method to analyze global transcription factor activity in cells reveals that a small number of factors determines the landscape of accessible chromatin.

Keywords:

Cell biology
Molecular biology
Protein activity
Transcription factor activity
Chromatin
Biology
Cell type
Cell fate determination
Transcription factor
Zinc finger
DNA
Human genome
Gene

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