The ultraviolet (UV) irradiation Induced Heat Hyperalgesia rat biomarker model for Pain Research

2008 
UV Radiation Exposure Animals were anaesthetized with a 2% isoflorane 02 mixture. Anesthesia was maintained via a nose cone while the plantar surface of the right paw was irradiated with 100, 200, 300 or 400mJ/cm of UV irradiation. This exposure was generated by Saalmann CupCube system (Saalmann GmbH, Germany; =280-400 nm). The source of irradiation was adapted to encompass the plantar surface of the rats hind paw by using a shaped delivery collar (either 8mm diameter or 8x12mm oval), attached to the UV emitter (Pfizer Facilities Management and Engineering Team). The intensity of UV emitted was calibrated prior to exposure using an ABLE 1400A radiometer with SEL005/WBS320/TD filter (ABLE Instruments and Controls Ltd).
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