Hypolipidemic effect of mannans from C. albicans serotypes a and B in acute hyperlipidemia in mice

Abstract Mannans, which are biological macromolecules of polysaccharide origin and function as immunomodulators, have been shown to stimulate macrophages in vivo by interaction with the mannose receptor. Thus, they can be used to stimulate macrophages in order to effectively remove circulating atherogenic lipoproteins. Our primary aim was to evaluate the hypolipidemic potential of mannans from C. albicans serotype A (mannan A) and serotype B (mannan B) in a murine model of hyperlipidemia. Mannan A and mannan B were shown to significantly (p  in vitro . Pre-treatment of CBA/Lac mice with mannan A prior to induction of hyperlipidemia significantly (p