The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Antonia Wallrapp,Samantha J. Riesenfeld,Patrick R. Burkett,Raja-Elie E. Abdulnour,Jackson Nyman,Danielle Dionne,Matan Hofree,Michael S. Cuoco,Christopher Rodman,Daneyal Farouq,Brian J. Haas,Timothy L. Tickle,John J. Trombetta,Pankaj Baral,Christoph S.N. Klose,Tanel Mahlakõiv,David Artis,Orit Rozenblatt-Rosen,Isaac M. Chiu,Bruce D. Levy,Monika S. Kowalczyk,Aviv Regev,Vijay K. Kuchroo

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

2017

Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

Keywords:

Inflammation
Innate lymphoid cell
Immunology
Lung
Transcriptome
Crosstalk
Biology
Neuropeptide
Receptor
Cell biology
Interleukin 17
Signal transduction
Neuromedin U
Allergic inflammation
Neuromedin U receptor
Interleukin 33

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