One-pot conversion of ketones to amides via Beckmann rearrangement catalyzed by metal chloride-ionic liquids under solvent-free condition

Abstract A catalytic system consisting of metal chloride-ionic liquids (ILs) was applied for one-pot conversion of ketones to amides via Beckmann rearrangement under solvent-free condition. The influence of the type of metal chlorides, type of ILs, length of the substituent chain on the cation of ILs, reaction temperature, and dosage of ILs was investigated. Various combinations of metal chlorides and ILs were found to be highly efficient for this reaction.