Penicillin Therapy in Early Syphilis. III.1|[ndash]|3

The results obtained in the treatment of early syphilis with penicillin have been presented by the writers in previous reports (1,2). In the previous studies, totals of 1.2 million and 2.4 million units, respectively, were administered in treatment schedules which utilized a three-hour interval between injections. The results were not considered to be the best obtainable with penicillin therapy. Subsequent to the publication of the above reports, studies of concentration of penicillin in blood serum (3) indicated that a two-hour interval between injections was more efficacious than a three-hour interval in maintaining a uniform blood level.