Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells

M. Lia Palomba,Kelly Piersanti,Carly G. K. Ziegler,Hugo Decker,Jesse W. Cotari,Kurt S. Bantilan,Ivelise Rijo,Jeff R. Gardner,Mark L. Heaney,Debra Bemis,Robert S. Balderas,Sami N. Malek,Erlene Seymour,Andrew D. Zelenetz,Marcel R.M. van den Brink,Grégoire Altan-Bonnet

Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells

2014

M. Lia Palomba
Kelly Piersanti
Carly G. K. Ziegler
Hugo Decker
Jesse W. Cotari
Kurt S. Bantilan
Ivelise Rijo
Jeff R. Gardner
Mark L. Heaney
Debra Bemis
Robert S. Balderas
Sami N. Malek
Erlene Seymour
Andrew D. Zelenetz
Marcel R.M. van den Brink
Grégoire Altan-Bonnet

Purpose Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation.

Keywords:

Chronic lymphocytic leukemia
Immunophenotyping
Cell signaling
Phosphorylation
Single-cell analysis
Signal transduction
Biology
Cell biology
breakpoint cluster region
Flow cytometry
Cancer research
Population
Syk
B cell

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