EZN-2208 treatment suppresses chronic lymphocytic leukaemia by interfering with environmental protection and increases response to fludarabine.

Roberta Valsecchi,Nadia Coltella,Daniela Magliulo,Lucia Bongiovanni,Lydia Scarfò,Paolo Ghia,Maurilio Ponzoni,Rosa Bernardi

EZN-2208 treatment suppresses chronic lymphocytic leukaemia by interfering with environmental protection and increases response to fludarabine.

2020

Roberta Valsecchi
Nadia Coltella
Daniela Magliulo
Lucia Bongiovanni
Lydia Scarfò
Paolo Ghia
Maurilio Ponzoni
Rosa Bernardi

The transcription factor HIF-1α is overexpressed in chronic lymphocytic leukaemia (CLL), where it promotes leukaemia progression by favouring the interaction of leukaemic cells with protective tiss...

Keywords:

Molecular biology
Fludarabine
Lymphocytic leukaemia
Hypoxia-inducible factors
Cancer research
Transcription factor
Biology

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