Preparation and Reactions of Functionalized Organocopper Reagents

Functionalized organocopper reagents have been prepared via an iodine-copper exchange by the reaction of aryl or alkenyl iodides with a sterically hindered cuprate reagent, lithium dineophylcuprate [(Me 2 PhCCH 2 ) 2 CuLi]. The resulting copper reagents react readily with various electrophiles leading to polyfunctionalized molecules. This method represents a unique protocol for the preparation of aryl-, heteroaryl- and alkenylcopper reagents.