Design of transdermal drug delivery system with PZT actuated micropump

Investigation of transdermal drug delivery system, based on silicon injector chip with silicon microneedles and PZT (lead zirconate titanate) actuated micropump, for drug delivery such as insulin is reported. First, basic skin properties and dosing requirements are reviewed. Next, the whole system and its components (injector chip, micropump, drug container) are discussed. Based on this, microneedles injector chip design is discussed and prototypes fabricated. Then, design of PZT actuated micropumps is discussed and prototypes fabricated. From measurements on fabricated micropumps, fluidic parameters are evaluated. Basic requirements for drug container, control electronics and power supply parameters are also presented. Finally, maximum drug delivery, based on measured prototype micropump parameters, through the prototype injector chip is determined.