Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease.

Glenn C Yiu,Eric Tieu,Anthony T. Nguyen,Brittany Wong,Zeljka Smit-McBride

Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease.

2016

Glenn C Yiu
Eric Tieu
Anthony T. Nguyen
Brittany Wong
Zeljka Smit-McBride

Purpose To employ type II clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 endonuclease to suppress ocular angiogenesis by genomic disruption of VEGF-A in human RPE cells.

Keywords:

CRISPR
Angiogenesis
Genome
Vascular endothelial growth factor A
Retinal
Genome editing
Gene
Endonuclease
Molecular biology
Biology
Mutation
Retinal pigment epithelium

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