An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
2007
The human thymus is given the difficult task of teaching T-cells which antigens are 'foreign' and which are 'self', a process which seems to go wrong in autoimmune disorders. A study of variation in the promoter of one gene expressed in thymus shows that one nucleotide change can disrupt gene regulation, and might lead to increased risk for autoimmune disease.
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