A high pressure effect on the vibrational spectra of ranitidine hydrochloride

Abstract The vibrational spectra of the ranitidine hydrochloride have been studied using Raman spectroscopy at pressures up to 11.2 GPa. At a pressure above 1.2 GPa a polymorphic phase transition from the initial form II to a new pressure induced form V has been observed. The vibration modes of the ranitidine hydrochloride as functions of pressure have been obtained. At pressures above 6.2 GPa, a gradual transformation to the amorphous phase of ranitidine hydrochloride has been revealed.