Indocyanine green provides absorption and spectral contrast for optical coherence tomography at 840 nm in vivo (Conference Presentation)

In recent years, there has been growing interest in the application of exogenous contrast agents to supplement the traditional strengths of optical coherence tomography (OCT). Here we present how indocyanine green (ICG), a common fluorescent contrast agent, can provide absorption and spectral contrast for OCT imaging in the mouse eye in vivo. We further demonstrate high stability of spectral contrast measurements for long term monitoring of contrast agents despite intensity fluctuations. This type of contrast-enhanced OCT may be able to provide similar information to ICG fluorescence angiography, but with the added benefit of depth-resolution and perfectly coregistered OCT intensity data.