Two new copper (II) complexes with sulfanilamide as ligand: Synthesis, structural, thermal analysis, electrochemical studies and antibacterial activity

2022 
Abstract Two new copper(II) complexes of sulfanilamide, namely [Cu3(C6H8N2O2S)4(C3H6NO)2Cl6]n (1) and [Cu(C6H8N2O2S)(C3H6NO)Cl2] (2), were synthesized and characterized by spectrometric methods, thermal analysis, single crystal X-ray diffraction and electrochemical investigation. In the crystal structures of both complexes, sulfanilamide is found to exhibit a monodentate behaviour coordinating through the amino nitrogen atom. In complex (1), the Cu(II) ions are five and six-coordinated with a square pyramidal and a slightly distorted octahedral geometry, respectively. Both structure of 1 and 2 have a 1D polymeric nature. In complex (2), the Cu(II) cations are six-coordinated with a slightly distorted octahedral geometry. Important interactions upon the molecular packing were also performed by the analysis of their Hirshfeld surfaces and compared to the 2D-fingerprint plots. Thermal stability of these crystalline materials has been investigated by thermogravimetric and differential thermal analysis (TG– DTA) technique and DSC curves, which showed that both complexes have high thermal stability and are stable up to 500°C. Thermogravimetric data have been utilized to assess the kinetic and thermodynamic parameters such as ∆S, ∆H and ∆G were determined by using the Coats-Redfern method. The electrochemical process was carried out by cyclic voltammetry in DMSO/ lithium perchlorate (LiClO4) 10−1 M as an electrolyte support, the Cu(II)/ Cu(I) redox system was found to be consistent with the quasi-reversible diffusion-controlled process. The antimicrobial activity of synthetized metal complexes against various tested organisms such as Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli and Pseudomonas aeruginosa) in different concentration reveals variable responses depending on the strain and the concentration of the compounds tested.
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