Synthesis of Lipid-Quantum Dots and the Fluorescence Resonance Energy Transfer of Quantum Dots in Lipid Bilayer

Hydrophilic CdTe and NIR CdHgTe QDs were successfully transferred from aqueous solution to nonpolar chloroform solvent via efficient phase transfer reagent to synthesize lipid-QDs. The liposomes showed bright fluorescence under the fluorescence microscope. It was confirmed that fluorescence resonance energy transfer (FRET) occurred between two types of QDs encapsulated in lipid bilayer with an excitation wavelength of 370nm, and the FRET efficiencies were satisfied (quenching efficiency was 51% and enhance efficiency was 40%), which laid a foundation for the research of drug release from liposomes.