Crystal structure of the aurora-2 protein and its binding pockets

A crystal belonging to the space group P3221 and having unit cell parameters of a = b = 87 ± 2A, c = 76 ± 2 A; α, β = 90 ° and γ = 120 ° comprising a molecule or molecular complex comprising amino acid residues 107-403 of SEQ ID NO: 1 of a protein kinase -2 unphosphorylated Aurora according to Figure 1, 2 , 3 or 4, wherein the root mean square deviation of the backbone atoms between amino acid residues of said molecule or molecular complex and said amino acid residues of Aurora-2 is not greater than 5 A.