A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica

A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation.