Theragnosis by MiR-141-3p Molecular Beacon: Simultaneous Detection and Sensitization of 5-Fluorouracil Resistant Colorectal Cancer Cells through the Activation of TRIM13-Associated Apoptotic Pathway

We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5-fluorouracil by hybridization with miR-141-3p, which is applicable to cancer treatment.