Gab2 protein and mRNA expression in lung cancer tissue and adjacent normal tissues.

Objective To know Gab2 protein and mRNA expression in lung cancer tissue and the adjacent normal tissues.Methods The expression of Gab2 protein was detected by PV-9003 immunohistochemical technique in 75 cases of lung cancer tissues and 25 cases of the adjacent tissues;Real-time RT-PCR was used to detect Gab2 mRNA expression in samples from 15 cases of lung cancer and matched adjacent cancer tissues.Results The positive rate of Gab2 protein in 30 cases of squamous cancer,30 cases of adenocarinoma and 15 other types of cancer was 66.67%,46.67% and 80% respectively,which was significantly higher than that in the adjacent normal tissues(P0.01);The positive rate of Gab2 mRNA in 15 cases of lung cancer tissues was significantly higher than that in the adjacent normal tissues(P0.05).Conclusion Over expression of Gab2 may play an important role in the development of lung cancer,may induce lung cancer.